Excellent suggestions! What a cast that would be. Jon Hamm? Joan Allen? Especially Carlos Bernard and Oded Fehr instead of the duds we got! (And Reiko on Lost was sadly wasted!)

Personally, I'd maybe go with Kelly McDonald for "Desdemona." ;) And while I like Molly Parker (loved her in 'Intensity') here's two other suggestions, fwiw:

In the age-appropriate range: Julianna Marguiles:


And also in the age-appropriate range, with tats: Pauley Perrette